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分類清單
劉燕雯
劉燕雯
職稱 專案助理教授
學歷 藥學博士;臺北醫學大學
經歷陽明大學生化暨分子生物研究所博士後研究
辦公室生物醫學大樓 五樓512室
電話886-2-28267000#5641
Emailskywenn@gmail.com;ywliu@ym.edu.tw<
研究方向
(1) 益生菌開發與應用:精神益生菌、機能性乳酸菌
(2) 益生菌藥理研究:免疫調節、菌腦腸軸線
(3) 次世代定序進行菌相研究

益生菌是有益於身體健康的細菌,益生菌幫助維持腸胃道健康、調節免疫、改善過敏、改善代謝症候群這些功效已被科學研究證實。隨著Gut-Brain-Axis的研究蓬勃發展,極少數益生菌可以經由神經系統、免疫系統、代謝等路徑影響中樞神經系統,調節mind, mood與behaviors,被稱為精神益生菌Psychobiotics。


我們研究室研究主軸是精神益生菌的開發與機制探討,已經發表亞洲第一株精神益生菌Lactobacillus plantarum PS128。目前持續利用憂鬱、焦慮、壓力、巴金森氏症、妥瑞症、自閉症等各種動物模式,開發精神益生菌。我們也已經建立運用細胞模式探討益生菌的益生特性與免疫反應,包括:inflammatory bowel diseases、irritable bowel syndrome、allergy、immunomodulation等。

研究著作

Yen-Wenn Liu#, Yen-Po Wang#, Hsu-Fang Yen, Pei-Yi Liu, Wen-Jian Tzeng, Chia-Fen Tsai, Han-Chieh Lin, Fa-Yauh Lee, One-Jang Jeng, Ching-Liang Lu*, Ying-Chieh Tsai*. (2019, Sep.) Lactobacillus plantarum PS128 Ameliorated Visceral Hypersensitivity through the Gut-Brain Axis in Rats. Probiotics and Antimicrobial Proteins, accepted (#equal contribution)

 

Kah Kheng GOH, Yen-Wenn Liu, Po-Hsiu Kuo, Yu-Chu Ella Chung, Mong-Liang Lu, Chun-Hsin Chen. (2019, Sep.)Effect of probiotics on depressive symptoms: a meta-analysis of human studies. Psychiatry Research, accepted

 

Yen-Wenn Liu#, Jia Sin Ong#, Chee Yuen Gan, Boon Yin Khoo, Sawibah Yahaya, Sy Bing Choi, Wai Yee Low, Ying-Chieh Tsai*, Min Tze Liong*. Lactobacillus fermentum PS150 showed psychotropic properties by altering serotonergic pathway during stress. Journal of Functional Foods 2019, 59: 352-361. (#equal contribution)

 

Li-Hao Cheng, Yen-Wenn Liu, Chien-Chen Wu, Sabrina Wang, Ying-Chieh Tsai*. Psychobiotics in mental health, neurodegenerative and neurodevelopmental disorders. Journal of Food and Drug Analysis 2019, 27(3): 632-648. (Review article)

 

Yen-Wenn Liu, Min Tze Liong, Yu-Chu Ella Chung, Hui-Yi Huang, Wu-Shun Peng, Yun-Fang Cheng, Yu-Siou Lin, Yu-Yu Wu*, Ying-Chieh Tsai*. Effects of Lactobacillus plantarum PS128 on Children with Autism Spectrum Disorder in Taiwan: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients 2019, 11(4): 820. https://doi.org/10.3390/nu11040820.

 

Jun Liu, Guo-Bing Wan, Ming-Shi Huang, George Agyapong, Tian-le Zou, Xue-ying Zhang, Yen-Wenn Liu, Yi-Qing Song, Ying-Chieh Tsai*, Xue-Jun Kong*. Probiotic Therapy for Treating Behavioral and Gastrointestinal Symptoms in Autism Spectrum Disorder: A Systematic Review of Clinical Trials. Current Medical Science. 2019, 39(2): 173-184. https://doi.org/10.1007/s11596-019-2016-4. (Review article)

 

Yu-Chu Ella Chung, Hsi-Chung Chen, Hsiang-Chin Lori Chou, I-Ming Chen, Meei-Shyuan Lee, Li-Chung Chuang, Yen-Wenn Liu, Mong-Liang Lu, Chun-Hsin Chen, Chi-Hsin Wu, Ming-Chyi Huang, Shih-Cheng Liao, Yen-Hsuan Nim, Mei-Shu Lai, Wei-Liang Shih*, Po-Hsiu Kuo*. Exploration of microbiota targets for major depressive disorder and mood related traits. Journal of Psychiatric Research. 2019, 111: 74-82.

 

Yen-Wenn Liu, Min-Tze Liong*, Ying-Chieh Tsai*. New perspectives of Lactobacillus plantarum as a probiotic: The gut-heart-brain axis. Journal of Microbiology. 2018, 56(9): 601-613. (Review article)

 

Yen-Wenn Liu, Wei-Kee Ong, Yu-Wen Su, Chih-Chieh Hsu, Tzu-Hao Cheng, Ying-Chieh Tsai*. Anti-inflammatory effects of Lactobacillus brevis K65 on RAW 264.7 cells and in mice with dextran sulphate sodium-induced ulcerative colitis. Beneficial Microbes. 2016, 7(3): 387-396.

 

Yen-Wenn Liu, Wei-Hsien Liu, Chien-Chen Wu, Yi-Chen Juan, Yu-Chen Wu, Huei-Ping Tsai, Sabrina Wang, Ying-Chieh Tsai*. Psychotropic effects of Lactobacillus plantarum PS128 in early life-stressed and naïve adult mice. Brain Research. 2016, 1631: 1-12.

 

Wei-Hsien Liu#, Yen-Wenn Liu#, Zih-Fong Chen, Wen-Fei Chiou, Ying-Chieh Tsai*, Chien-Chih Chen*. Calophyllolide content in Calophyllum inophyllum at different stages of maturity and its osteogenic activity. Molecules. 2015, 20: 12314-12327. (#equal contribution)

 

Yen-Wenn Liu, Tzu-Yen Fu, Wu-Shun Peng, Yu-Han Chen, Yong-Mei Cao, Chun-Chiang Chen, Wei-Lian Hung, Ying-Chieh Tsai*. Evaluation of the potential anti-allergic effects of heat-inactivated Lactobacillus paracasei V0151 in vitro, ex vivo, and in vivo. Beneficial Microbes. 2015;6(5):697-705. (IF=2.923; R/C=41/123, MICROBIOLOGY)

 

Yu-Ling Huang, Chia-Hsin Lee, Jyh-Fei Liao, Yen-Wenn Liu, Wen-Fei Chiou*. Protective effects of ugonin K on hydrogen peroxide-induced osteoblast cell damage. Journal of Functional Foods. 2015, 15: 487-496. (IF=3.144; R/C= 8/125, FOOD SCIENCE & TECHNOLOGY)

 

Phoebe B. Chen, Hsiao-Chi Wang, Yen-Wenn Liu, Shih-Hang Lin, Lee-Yan Sheen*. Immunomodulatory activities of polysaccharides from Chlorella pyrenoidosa in a mouse model. Journal of Functional Foods. 2014, 11: 103-113. (IF=3.144; R/C= 8/125, FOOD SCIENCE & TECHNOLOGY)

 

Yen-Wenn Liu, Tan-Wei Liao, Yu-Han Chen, Yi-Chin Chiang, Ying-Chieh Tsai*.Oral administration of heat-inactivated Lactobacillus plantarum K37 modulated airway hyperresponsiveness in ovalbumin-sensitized BALB/c mice. PLoS One. 2014, 9(6): e100105. (IF=2.806; R/C=11/63, MULTIDISCIPLINARY SCIENCES)

 

Yen-Wenn Liu, Hui-Ching Mei, Yu-Wen Su, Hsiu-Tzu Fan, Chien-Chih Chen*, Ying-Chieh Tsai*. Inhibitory activities of Pleurotus tuber-regium mycelia and bioactive constituents on LPS-induced proinflammatory responses in RAW 264.7 cells. Journal of Functional Foods. 2014, 7: 662-670.

 

Wen-Fei Chiou*, Yu-Ling Huang, Yen-Wenn Liu. (+)-Vitisin A Inhibits Osteoclast Differentiation by Preventing TRAF6 Ubiquitination and TRAF6-TAK1 Formation to Suppress NFATc1 Activation. PLoS One. 2014, 9(2): e89159.

 

Hsueh-Ting Chu, Han Lin, Tsun-Hui Tsao, Chun-Fan Chang, William WL Hsiao, Tze-Jung Yeh, Ching-Mao Chang, Yen-Wenn Liu, Tse-Yi Wang, Ko-Chun Yang, Chen TJ, Tsung-Jui Chen, Jen-Chih Chen, Kuang-Chi Chen, Cheng-Yan Kao*. Genotyping of human neutrophil antigens (HNA) from whole genome sequencing data. BMC Medical Genomics. 2013;6:31. doi: 10.1186/1755-8794-6-31.

 

Yu-Ling Huang, Yen-Wenn Liu, Yu-Jou Huang, Wen-Fei Chiou*. A special ingredient (VtR) containing oligostilbenes isolated from Vitis thunbergii prevents bone loss in ovariectomized mice: in vitro and in vivo study. Evidence-Based Complementary and Alternative Medicine. 2013, 2013: 409421. doi: 10.1155/2013/409421.

 

Hsueh-Ting Chu, William W. L. Hsiao, Jen-Chih Chen, Theresa Tsun-Hui Tsao, Tze-Jung Yeh, Mong-Hsun Tsai, Han Lin, Yen-Wenn Liu, Sheng-An Lee, Chaur-Chin Chen, Cheng-Yan Kao*. EBARDenovo: Highly accurate de novo assembly of RNA-Seq with efficient chimera-detection. Bioinformatics, 2013, 29(8): 1004-1010. doi: 10.1093/bioinformatics/btt092.

 

Hui-Ching Mei, Yen-Wenn Liu, Yi-Chin Chiang, Shiou-Huei Chao, Nai-Wen Mei, Yu-Wen Liu, Ying-Chieh Tsai*. Immunomodulatory activity of Lactococcus lactis subsp. lactis A17 from Taiwan fermented cabbage in OVA-sensitized BALB/c mice. Evidence-Based Complementary and Alternative Medicine. 2013; 2013: 287803. doi: 10.1155/2013/287803.

 

Hsueh-Ting Chu, William W. L. Hsiao, Theresa Tsun-Hui Tsao, Ching-Mao Chang, Yen-Wenn Liu, Chen-Chieh Fan, Hen-Hong Chang, Tze-Jung Yeh, Jen-Chih Chen, Chaur-Chin Chen, Cheng-Yan Kao*.Quantitative assessment of mitochondrial DNA copies from whole genome sequencing as a biomarker of aging. BMC Genomics. 2012; 13 Suppl 7: S5. doi: 10.1186/1471-2164-13-S7-S5.

 

Yen-Wenn Liu, Kuan-Hung Lu, Chi-Tang Ho, Lee-Yan Sheen*. Protective effects of Antrodia cinnamomea against liver injury. Journal of Traditional and Complementary Medicine. 2012. Oct. 2: 284-294. (Review Article)

 

Yeh-Lin Lu, Cho-Yun Chia, Yen-Wenn Liu, Wen-Chi Hou*. The Biological activity and applications of dioscorins, yam major tuber storage proteins. Journal of Traditional and Complementary Medicine. 2012. 2: 41-46. (Review Article)

 

Yen-Wenn Liu, Yu-Wen Su, Wei-Kee Ong, Tzu-Hao Cheng*, Ying-Chieh Tsai*. Oral administration of Lactobacillus plantarum K68 ameliorates DSS-induced ulcerative colitis in BALB/c mice via the anti-inflammatory and immunomodulatory activities. International Immunopharmacology. 2011. 11: 2159-2166.

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