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廖韋晴
廖韋晴
  • 職稱: 助理教授
  • 學歷: Ph.D., Department of Chemistry, National Tsing Hua University
  • 經歷:Post-doc, Institute of Chemistry, The Hebrew University of Jerusalem
  • 辦公室: 傳醫乙棟 五樓508室
  • 電話: 886-2-2826-7124
  • Emailliaowc@ym.edu.tw
  • 實驗室網頁https://liaowc.wixsite.com/site

研究領域

(1) 刺激響應核酸膠囊:利用具生物相容性之核酸分子,自組裝形成包裹藥物或顯影試劑之球狀膠囊,以功能性核酸做為載體開關設計在核酸膠囊殼層中,當功能性核酸感測到不同疾病特有之生物標記刺激時,會選擇性地依環境中存在的生物標記種類及濃度,引起膠囊結構改變並開啟,進而釋放藥物。

(2) 新型催化性核酸 (Nucleoapzymes):為了在核酸奈米技術的整合應用上更靈活多變,催化性核酸的設計概念,是模擬蛋白質酵素同時具有基質的結合位點與活性位點,在設計上將DNA酵素 (DNAzymes) 與核酸適體 (aptamers) 鍵結,探討鍵結距離與方位 (3’或5’端) 對催化活性之影響,以篩選設計不同用途與催化活性之新型催化性核酸。

(3) 生物感測平台:為達到快速、精準的分析物檢測,運用生物分子 (如:核酸、抗體) 特有之專一性進行分析物的識別,結合各類型的訊號放大轉換機制,像是具催化性質的人造奈米材料 (nanozymes),將分析物的訊息轉換為電化學或光學信號,並從中進行訊號放大。


研究著作

 

  • Liao, W.-C.; Lilienthal, S.; Kahn, J. S.; Riutin, M.; Sohn, Y. S.; Nechushtai, R.; Willner, I. pH- and Ligand-Induced Release of Loads from DNA-Acrylamide Hydrogel Microcapsules. Chem. Sci. 2017, 8, 3362-3373.

 

  • Wang, S.; Cazelles, R.; Liao, W.-C.; Vázquez-González, M.; Zoabi, A.; Abu-Reziq, R.; Willner, I. Mimicking Horseradish Peroxidase and NADH Peroxidase by Heterogeneous Cu2+-Modified Graphene Oxide Nanoparticles. Nano Lett. 2017, 17, 2043-2048.

 

  • Vázquez-González, M.; Liao, W.-C.; Cazelles, R.; Wang, S.; Yu, X.; Gutkin, V.; Willner, I. Mimicking Horseradish Peroxidase Functions Using Cu2+-Modified Carbon Nitride Nanoparticles or Cu2+-Modified Carbon Dots as Heterogeneous Catalysts. ACS Nano 2017, 11, 3247-3253.

 

  • Liao, W.-C.; Riutin, M.; Parak, W. J.; Willner, I. Programmed pH-Responsive Microcapsules for the Controlled Release of CdSe/ZnS Quantum Dots. ACS Nano 2016, 10, 8683-8689. Highlighted on nanotechweb.org, Aug 29, 2016. pH-Responsive DNA Capsules Release QD Loads, available at: http://nanotechweb.org/cws/article/tech/66042

 

  • Liao, W.-C.; Sohn, Y. S.; Riutin, M.; Cecconello, A.; Parak, W. J.; Nechushtai, R.; Willner, I. The Application of Stimuli-Responsive VEGF- and ATP-Aptamer-Based Microcapsules for the Controlled Release of an Anticancer Drug, and the Selective Targeted Cytotoxicity toward Cancer Cells. Adv. Funct. Mater. 2016, 26, 4262-4273.

 

  • Huang, F.; Liao, W.-C.; Sohn, Y. S.; Nechushtai, R.; Lu, C.-H.; Willner, I. Light-Responsive and pH-Responsive DNA Microcapsules for Controlled Release of Loads. J. Am. Chem. Soc. 2016, 138, 8936–8945.

 

  • Golub, E.; Albada, H. B.; Liao, W.-C.; Biniuri, Y.; Willner, I. Nucleoapzymes: Hemin/G-Quadruplex DNAzyme–Aptamer Binding Site Conjugates with Superior Enzyme-like Catalytic Functions. J. Am. Chem. Soc. 2016, 138, 164–172.

 

  • Liao, W.-C.; Lu, C.-H.; Hartmann, R.; Wang, F.; Sohn, Y. S.; Parak, W. J.; Willner, I. Adenosine Triphosphate-Triggered Release of Macromolecular and Nanoparticle Loads from Aptamer/DNA-Cross-Linked Microcapsules. ACS Nano 2015, 9, 9078–9086. Highlighted on nanotechweb.org, Aug 24, 2015. Cross-Linked Microcapsules Release Anti-Cancer Drugs, available at: http://nanotechweb.org/cws/article/tech/62303

 

  • Lin, C.-H.; Liao, W.-C.; Chen, H.-K.; Kuo, T.-Y. Paper Spray-MS for Bioanalysis. Bioanalysis 2014, 6, 199–208.

 

  • Liao, W.-C.; Annie Ho, J.-a. Improved Activity of Immobilized Antibody by Paratope Orientation Controller: Probing Paratope Orientation by Electrochemical Strategy and Surface Plasmon Resonance Spectroscopy. Biosens. Bioelectron. 2014, 55, 32–38.

 

  • Liao, W.-C.; Chuang, M.-C.; Ho, J.-a. A. Electrochemical Sensor for Multiplex Screening of Genetically Modified DNA: Identification of Biotech Crops by Logic-Based Biomolecular Analysis. Biosens. Bioelectron. 2013, 50, 414–420.

 

  • Ho, J.-a. A.; Hsu, W.-L.; Liao, W.-C.; Chiu, J.-K.; Chen, M.-L.; Chang, H.-C.; Li, C.-C. Ultrasensitive Electrochemical Detection of Biotin Using Electrically Addressable Site-Oriented Antibody Immobilization Approach via Aminophenyl Boronic Acid. Biosens. Bioelectron. 2010, 26, 1021–1027.

 

  • Liao, W.-C.; Ho, J.-a. A. Attomole DNA Electrochemical Sensor for the Detection of Escherichia coli O157. Anal. Chem. 2009, 81, 2470–2476.

 

  • Cheng, Y. J.; Liao, W.-C.; Wang, C. M. Proton-Assisted Iron(III) Recognition with 4,4’-(4,5-Diaminonaphthalen-1,8-Yldiazo)-Bisbenzenesulfonate. J. Electroanal. Chem. 2008, 612, 15–21.

 

  • Viswanathan, S.; Liao, W.-C.; Huang, C.-C.; Hsu, W.-L.; Ho, J.-a. A. Rapid Analysis of L-Dopa in Urine Samples Using Gold Nanoelectrode Ensembles. Talanta 2007, 74, 229–234.

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