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分類清單
陳威儀
陳威儀
職稱 助理教授
學歷 PhD. National Defense Medical College (Institute of Life Science)
經歷 Postdoc. Lab of Biochemistry and Molecular Biology, Rockefeller University, USA
辦公室 生物醫學大樓 七樓 R711 室
電話 886-2-2826-7328
Email chenwy@ym.edu.tw
學經歷
2014迄今 國立陽明大學 生化暨分子生物研究所 助理教授
2014-2016   美國洛克菲勒大學 生化暨分子生物實驗室 訪問學者
2005-2007 中央研究院 分子生物所 博士後研究員
2000-2005國防醫學院、中研院、國衛院合辦生命科學研究所 博士
榮譽
2019國立陽明大學 生命科學院 教學優良教師
2008-2011   美國血癌及淋巴癌基因會 博士後研究學者
2006 國科會 菁英博士後研究獎助
2006 王民寧基金會 博士班優秀論文獎
專長-- Transcriptional Regulatory Mechanism of B cell Lymphopoiesis and Leukemogenesis
研究方向
Antibody producing B cells arise from hematopoietic stem cells through a series of developmental steps that involve a hierarchical transcription factor network. Whereas much is known about their direct genetic targets, little is known about their actual mechanism of action through interactions with various coactivators that act on chromatin structure or on the general transcription machinery. In addition, genetic mutations of the involved transcription factors result in loss-of-function or gain-of-function frequently lead to B cell deficiency or malignancy.
Our goal is to uncover the mechanisms by which transcriptional activators/coactivators (including various histone modifiers/remodelers) control the development and leukemogenesis of B-lymphocytes, as well as searching therapeutic targets/approaches for B-cells associated leukemia/lymphoma.
On-going studies will employ various state-of-the-art biomedical technologies that include:
1. biochemically isolating recombinant proteins/ protein complexes from bacteria/insect/mammalian cell cultures for cell-free assays
2. genome-widely profiling (ChIP-seq and RNA-seq) the transcription-related factors (DNA-binding proteins and transcriptional coactivators) and corresponding histone modifications in normal or malignant cells
3. developing the peptidomimetics for potential therapeutic to leukemia/lymphoma treatment
研究著作

Shimada M, Chen W-Y, Nakadai T, Onikubo T, Guermah M, Rhodes D, Roeder RG. Gene-Specific H1 Eviction through a Transcriptional Activator→p300→NAP1→H1 Pathway. Molecular Cell 2019; 74, 268-283.

 

Chang CH, Zanini M, Shirvani H, Cheng JS, Yu H, Feng CH, Mercier AL, Hung SY, Forget A, Wang CH, Cigna SM, Lu IL, Chen W-Y, Leboucher S, Wang WJ, Ruat M, Spassky N, Tsai JW, Ayrault O. Atoh1 Controls Primary Cilia Formation to Allow for SHH-Triggered Granule Neuron Progenitor Proliferation. Developmental Cell 2019; 48, 184-199.

 

Chen YL, Hu CM, Hsu JT, Chang CC, Huang TY, Chiang PH, Chen W-Y, Chang YT, Chang MC, Tien YW, Lee EY, Jeng YM, Lee WH. Cellular 5-hydroxylmethylcytosine content determines tumorigenic potential and prognosis of pancreatic ductal adenocarcinoma. American Journal of Cancer Research 2018; 8, 2548-2563.

 

Jishage M, Yu X, Shi Y, Ganesan SJ, Chen W-Y, Sali A, Chait BT, Asturias FJ, Roeder RG. Architecture of Pol II(G) and molecular mechanism of transcription regulation by Gdown1. Nature Structure and Molecular Biology 2018; 25, 859-867.

 

Wu HT, Kuo YC, Hung JJ, Huang CH, Chen WY, Chou TY, Chen Y, Chen YJ, Chen YJ, Cheng WC, Teng SC, Wu KJ. K63-polyubiquitinated HAUSP deubiquitinates HIF-1α and dictates H3K56 acetylation promoting hypoxia-induced tumour progression. Nature Communications 2016; 7, 13644.

 

Lu R, Wang P, Parton T, Zhou Y, Chrysovergis K, Rockowitz S, Chen W-Y, Abdel-Wahab O, Wade PA, Zheng D, Wang GG. Epigenetic Perturbations by Arg882-Mutated DNMT3A Potentiate Aberrant Stem Cell Gene-Expression Program and Acute Leukemia Development. Cancer Cell 2016; 30, 92-107.

 

Jiang BH, Chen W-Y, Li HY, Chien Y, Chang WC, Hsieh PC, Wu P, Chen CY, Song HY, Chien CS, Sung YJ, Chiou SH. CHD1L regulated PARP1-driven Pluripotency and Chromatin Remodeling during the Early-stage Cell Reprogramming. Stem Cells 2015; 33, 2961-2972.

 

Geng H, Hurtz C, Lenz KB, Chen Z, Baumjohann D, Thompson S, Goloviznina NA, Chen W-Y, Huan J, LaTocha D, Ballabio E, Xiao G, Lee JW, Deucher A, Qi Z, Park E, Huang C, Nahar R, Kweon SM, Shojaee S, Chan LN, Yu J, Kornblau SM, Bijl JJ, Ye BH, Ansel KM, Paietta E, Melnick A, Hunger SP, Kurre P, Tyner JW, Loh ML, Roeder RG, Druker BJ, Burger JA, Milne TA, Chang BH, Müschen M. Self-enforcing feedback activation between BCL6 and pre-B cell receptor signaling defines a distinct subtype of acute lymphoblastic leukemia. Cancer Cell 2015; 27, 409-425.

 

Cheng KW, Cheng SC, Chen W-Y, Lin MH, Chuang SJ, Cheng IH, Sun CY, Chou CY. Thiopurine analogs and mycophenolic acid synergistically inhibit the papain-like protease of Middle East respiratory syndrome coronavirus. Antiviral Research 2015; 115, 9-16.

 

Chen C-H, Chen W-Y, Lin S-F, and Wong RJ. Epithelial–Mesenchymal Transition Enhances Response to Oncolytic Herpesviral Therapy Through Nectin-1. Human Gene Therapy 2014; 25, 539-551.

 

Chen W-Y, Zhang J, Geng H, Du Z, Nakadai T, and Roeder RG. A TAF4 coactivator function for E proteins that involves enhanced TFIID binding. Genes and Development 2013; 27:1596-1609.

 

Tang Z, Chen W-Y, Shimada M, Nguyen UTT, Kim J, Sun XJ, Sengoku T, McGinty RK, Fernandez JP, Muir TW, and Roeder RG. SET1 and p300 synergy, through coupled histone modifications, in transcriptional activation by p53. Cell 2013; 154, 297-310.

 

Sun XJ, Wang Z, Wang L, Jiang Y, Kost N, Soong TD, Chen W-Y, Tang Z, Nakadai T, Elemento O, Fischle W, Melnick A, Patel DJ, Nimer SD, and Roeder RG. A stable transcription factor complex nucleated by oligomeric AML1-ETO controls leukemogenesis. Nature 2013; 500: 93-97.

 

Cai L, Rothbart SB, Lu R, Xu B, Chen W-Y, Tripathy A, Rockowitz S, Zheng D, Patel DJ, Allis CD, Strahl BD, Song J, and Wang GG. An H3K36 methylation engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting. Molecular Cell 2013; 49: 571-582.

 

Geng H, Brennan S, Milne TA, Chen W-Y, Li Y, Hurtz C, Kweon SM, Zickl L, Shojaee S, Neuberg D, Huang C, Biswas D, Xin Y, Racevskis J, Ketterling RP, Luger SM, Lazarus H, Tallman MS, Rowe JM, Litzow MR, Guzman ML, Allis CD, Roeder RG, Muschen M, Paietta E, Elemento O, Melnick AM. Integrative Epigenomic Analysis Identifies Biomarkers and Therapeutic Targets in Adult B-Acute Lymphoblastic Leukemia. Cancer Discovery 2012; 2: 1004-1023.

 

Jiang H, Shukla A, Wang X, Chen W-Y, Bernstein BE, and Roeder RG. Role for Dpy-30 in ES cell-fate specification by regulation of H3K4 methylation within bivalent domains. Cell 2011;144: 513-525.

 

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