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分類清單
郭津岑
郭津岑
職稱 副教授
學歷 PhD. Institute of Molecular Medicine, National Taiwan University, Taiwan
經歷 Research Fellow, National Heart, Lung and Blood Institute (NHLBI), National Institute of Health (NIH), USA
辦公室 生物醫學大樓 五樓 R515 室
電話 886-2-2826-7120
Email jckuo@ym.edu.tw
 
經歷
2015 迄今

國立陽明大學 生化暨分子生物研究所 副教授

2011-2015

國立陽明大學 生化暨分子生物研究所 助理教授

2012

美國加州大學聖地牙哥分校(UCSD) 醫學工程研究所 訪問學者

2011

美國國家衛生研究院(NHLBI/NIH) 研究員

2006-2011    

The Scripps Research Institute 細胞生物學系/美國家衛生研究院(NHLBI/NIH) 博士後研究員

2005-2006

國立台灣大學分子醫學研究所 / 中央研究院生物化學研究所 博士後研究員

榮譽
2018   

國立陽明大學 教學優良獎

2018

科技部 吳大猷先生紀念獎

2017-2018    

國立陽明大學 教師學術卓越獎勵

2018

國立陽明大學醫學院 學生網路教學評估優良教師

2017

國立陽明大學醫學院 學生網路教學評估優良教師

2016

國立陽明大學醫學院 學生網路教學評估優良教師

2015-2016

國立陽明大學 教師學術卓越獎勵

2014

紀念沈力揚教授講師級研究與進修獎助

2014-2018

科技部 優秀年輕學者計畫

2012-2015

科技部 優秀年輕學者計畫

2010

美國國家衛生研究院 (NIH) FARE Award (Fellow Award for Research Excellence)

2007-2011

美國國家衛生研究院 (NIH) Intramural Research Awards

指導學生獲獎
2019

指導林中煒榮獲生物醫學聯合學術年會優秀論文壁報獎

2017   

指導吳旻璁榮獲生命科學院獎學金

2016

指導歐孟鑫榮獲生物醫學聯合學術年會優秀論文壁報獎

2016

指導吳睿中榮獲五鼎獎學金

2015

指導陳勝怡榮獲科技部大專生專題研究計畫

2015

指導陳羽真榮獲陽明大學生命科學院院長獎

2015

指導陳羽真榮獲林榮耀教授學術教育基金會 優秀論文壁報獎

2015

指導藍天韻榮獲五鼎獎學金

2015

指導吳睿中榮獲科技部補助博士班出國參加 The ASCB Annual meeting in San Diego

2015

指導吳睿中榮獲中華扶輪獎學金

2014

指導吳睿中榮獲生物醫學聯合學術年會優秀論文壁報獎

2014

指導尤文心榮獲生物醫學聯合學術年會優秀論文壁報獎

2013

指導黃奕璇榮獲紀念尹珣若先生品學及論文優良獎學金優等獎

2013

指導黃奕璇榮獲陽明大學學術論文比賽佳作獎

專利與技轉
專利名稱:Fibronectin in cell adhesion and migration via N-glycosyaltion (纖維連接蛋白純化技術)
發明人:Jean-Cheng Kuo (郭津岑)
US provision Filing No.:62399688 (Filing Date: 2016年10月11日)
技轉:嘉生細胞科技股份有限公司 (2016年11月-2022年11月)
專利名稱:製備改良豬血漿纖連接蛋白以增強傷口癒合之應用
發明人:Jean-Cheng Kuo (郭津岑)
中華民國發明專利案號:106132649 (核准日: 2019年08月29日)
技轉:嘉生細胞科技股份有限公司 (2016年11月-2022年11月)
專長--幹細胞治療相關研究、癌症生物學、細胞骨架力學及生理功能、生化及分子生物學
研究方向
(一) 幹細胞分化及癌症轉移的研究:細胞在生理微環境中透過黏著斑 (focal adhesions)的形成與細胞外間質(extracellular matrix)貼附,以感受並傳遞細胞外間質的生化及物理性刺激(包括: 細胞外間質組成、硬度、孔隙大小及形狀),進而轉化為細胞內的生物信號,以調節細胞各式生理功能(包括:細胞分裂、分化、細胞移動及凋亡)。本實驗室透過各種模擬人體條件的狀況下,結合蛋白質體學分析及高階顯微鏡技術以探討間葉幹細胞分化及癌細胞轉移的調控機轉及應用。
Stem cell differentiation and cancer metastasis: We focus on the topic of the mechanosensitivity of integrin-based focal adhesions, which allow cells to sense and translate biochemical and physical cues from their environment (extracellular matrix components, stiffness or organization) into cellular biological signals that control cell behavior, differentiation, and death. My group focus on investigating how the signals of integrin-based focal adhesions regulate stem cell fate, myogenesis and cancer metastasis.
(二)傷口癒合材料的開發:纖維連接蛋白(fibronectin)為已知促進細胞移動的細胞外間質蛋白,本實驗室開發纖維連接蛋白純化之專利技術,將持續開發為傷口癒合材料。
Development of wound healing materials: We have developed a patented method to purify fibronectin. Using the purified fibronectin, my group keep developing the medical materials for wound healing.
研究著作

Cheng HW, Hsiao CT, Chen YQ, Huang CM, Chan SI, Chiou A, Kuo JC*. Centrosome guides spatial activation of Rac to control cell polarization and directed cell migration. Life Sci Alliance. 8; 2(1). 2019.

 

Chen YQ*, Kuo JC, Wei MT, Chen YC, Yang MH, Chiou A*. Early stage mechanical remodeling of collagen surrounding head and neck squamous cell carcinoma spheroids correlates strongly with their invasion capability. Acta Biomater. 15; 84:280-292. 2019.

 

Luo R, Chen PW, Kuo JC, Jenkins L, Jian X, Waterman CM, Randazzo PA*. ARAP2 inhibits Akt independently of its effects on focal adhesions. Biol Cell. 110(12): 257-270. 2018.

 

Hsiao CT, Cheng HW, Huang CM, Lee HR, Ou MH, Huang JR, Khoo KH, Yu HW, Chen YQ, Wang YK, Chiou A, Kuo JC*. Fibronectin in cell adhesion and migration via N-glycosylation. Oncotarget 8 (41): 70653-70668. 2017.

 

Chuang TY, Cheng AJ, Lan TY, Huang IH, Shiau CW, Hsu CL, Liu YW, Tseng PH, Chang ZF, Kuo JC*. Suppression of LPS-induced inflammatory responses by the hydroxyl groups of dexamethasone. Oncotarget. 8: 49735-49748. 2017.

 

Chakraborty S, Ou MH, Kuo JC, Chiou A*. A comparative study of metabolic state of stem cells during osteogenic and adipogenic differentiations via fluorescence lifetime imaging microscopy. Proc. of SPIE Vol. 10024:100243Y. 2016.

 

Wu TH, Kuo YY, Lee HH, Kuo JC, Ou MH, Chang ZF*. Epigenetic repression of ribosomal RNA transcription by ROCK-dependent aberrant cytoskeletal organization. Sci. Rep. 6:28685. 2016.

 

Wu JC, Chen YC, Chen YQ Chen, Chiou A, Kuo JC*. Focal adhesion kinase-dependent focal adhesion recruitment of SH2 domains directs SRC into focal adhesions to regulate cell adhesion and migration. Scientific Report. 5:18476 . 2015.

 

Wang HL, Yang CH, Lee HH, Kuo JC, Hur SS, Chien S, Lee OK, Hung SC, Chang ZF*. Dexamethasone-induced cellular tension requires SGK1-stimulated Sec5/GEF-H1 interaction. J Cell Sci. 128(20):3757-68. 2015.

 

Yu HW, Chen YQ, Huang CM, Liu CY, Chiou A, Wang YK, Tang MJ, Kuo JC*. b-PIX controls intracellular viscoelasticity to regulate lung cancer cell migration. J Cell Mol Med. 19(5): 934-947. 2015.

 

Huang IH, Hsiao CT, Shen RF, Liu CY, Wang YK, Chen YC, del Alamo JC, Chang ZF, Tang MJ, Khoo KH, Kuo JC*.GEF-H1 controls focal adhesion signaling that regulates mesenchymal stem cell lineage commitment. J Cell Sci.127:4186-4200. 2014. * This paper was selected to be the main Journal of Cell Science October cover.

 

Kuo JC*. Focal adhesions function as a mechanosensor. Progress in Molecular Biology and Translational Science. 126:55-73. 2014.

 

Yuan WC, Lee YR, Lin SY, Chang LY, Tan YP, Hung CC, Kuo JC, Liu CH, Lin MY, Xu M, Chen ZJ, Chen RH*. K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20 Ubiquitin E3 Ligase Regulates Protein Trafficking. Mol. Cell pii: S1097-2765(14)00268-8. 2014.

 

Kuo JC*. Mechanotransduction at focal adhesions: integrating cytoskeletal mechanics in migrating cells. J Cell Mol Med.17(6):704-712. 2013.

 

Chen DY, Li MY, Wu SY, Lin YL, Tsai SP, Lai PL, Lin YT, Kuo JC, Meng TC, Chen GC*. The Bro1 domain-containing Myopic/HDPTP coordinates with Rab4 to regulate cell adhesion and migration. J Cell Sci. 125(pt20): 4841-52. 2012.

 

Kuo JC, Han X, Yates JR, Waterman CM*. Isolation of focal adhesion proteins for biochemical and proteomic analysis. Method Mol. Biology (Integrin and Cell Adhesion Molecules). 757:297-323. 2012.

 

Li CC, Kuo JC, Kiyama R, Moss J, Vaughan M*. Brefeldin A-inhibited guanine nucleotide-exchange protein (BIG) 1 and KANK1 participate in modulating cell polarity and directed migration during wound healing. PNAS. 108(48):19228-33. 2011.

 

Valdes JL, Tang J, Mcdermott MI, Kuo JC, Zimmerman SP, Wincovitch SM, Waterman CM, Milgram SL, Playford MP*. Sorting Nexin 27 mediates PDZ-directed targeting of a β-Pix-Git complex to focal adhesions. J. Biol. Chem. 286(45):39403-16. 2011.

 

Kuo JC, Han X, Hsiao CT, Yates JR, Waterman CM*. Analysis of the myosinII-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13(4):383-93. 2011. *This paper was selected to be the main Nature Cell Biology April cover, and was the subject of the news and views in Nature Cell Biology (Joan S. Brugge, 13: 344, 2011) and a research highlight in Nature Reviews Molecular Cell Biology (Katrin Legg, 12:278, 2011).

Myosin II-Responsive Focal Adhesion Proteome : http://dir.nhlbi.nih.gov/papers/lctm/focaladhesion/Home/index.html

 

Wang WJ, Kuo JC, Ku W, Lee YR, Lin FC, Chang YL, Lin YM, Chen CH, Huang YP, Chiang MJ, Yeh SW, Wu PR, Shen CH, Wu CT, and Chen RH*. The tumor suppressor DAPK is reciprocally regulated by tyrosine kinase Src and phosphatase LAR. Mol. Cell. 27(5):701-16. 2007.

 

Kuo JC, Wang WJ, Yao CC, Wu PR, and Chen RH*. The tumor suppressor DAPK inhibits cell motility by blocking integrin-mediated polarity pathway. J Cell Biol. 172(4): 619-31. 2006.

 

Chen RH*, Wang WJ, and Kuo JC. The tumor suppressor DAP-kinase links cell adhesion and cytoskeleton reorganization to cell death regulation. J Biomed Sci. 3: 1-7. 2006.

 

Chen CH, Wang WJ, Kuo JC, Tsai HC, Lin JR, Chang ZF, Chen RH*. Bidirectional signals transduced by DAPK-ERK interaction promote the apoptotic effect of DAPK. EMBO J. 24: 294-304. 2005.

 

Kuo JC, Lin JR, Staddon JM, Hosoya H, Chen RH*. Uncoordinated regulation of stress fibers and focal adhesions by DAP kinase. J Cell Sci. 116: 4777-4790. 2003.

 

Wang WJ, Kuo JC, Yao CC, Chen RH*. DAP-kinase induces apoptosis by suppressing integrin activity and disrupting matrix survival signals. J Cell Biol. 159: 169-79. 2002.

 

 

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