Your browser does not support JavaScript!
林達顯
image
研究領域
利用多維異核核磁共振技術從結構的觀點探討生物巨分子之功能。「動脈粥狀硬化」和「阿茲海默症」等老年退化性疾病相關的生物巨分子之結構生物學研究,例如載脂蛋白E(apolipoprotein E)與脂質交互作用之機制及β-類澱粉胜肽(β-amyloid peptide)聚集與阿茲海默症致病機制之關係;開發去泛素化酶(Ubiquitin specific protease, USP)之抑制劑,作為癌症藥物之先導化合物;探討磷酸化如何調控蛋白磷酸酶-1(protein phosphatase-1)與其蛋白抑制劑(protein inhibitors)之交互作用。
研究著作
  • Chu-Ting Liang, Yu-Shan Lin, Yi-Choang Huang, Hsien-Lu Huang, Jia-Qian Yang, Tsung-Hsien Wu, Chi-Fon Chang, Shing-Jong Huang, Hsien-Bin Huang* & Ta-Hsien Lin* Characterization of the interactions between inhibitor-1 and recombinant PP1 by NMR spectroscopy, 2018, Scientific reports, 8, Article number: 50.

 

  • Chun-Tien Kuo, Yi-Lin Chen, Wei-Tse Hsu, Su-Chun How, Yu-Hong Cheng, Shu-Shun Hsueh, Hwai-Shen Liu, Ta-Hsien Lin, Josephine W. Wu*, Steven S.-S. Wang* Investigating the effects of erythrosine B on amyloid fibril formationderived from lysozyme, 2017, International Journal of Biological Macromolecules, 98, 159–168.

 

  • Chu-Ting Liang, Hsien-Bin Huang, Chih-Ching Wang, Yi-Ru Chen, Chi- Fon Chang, Ming-Shi Shiao, Yi-Cheng Chen*, Ta-Hsien Lin* L17A/F19A Substitutions Augment the α-Helicity of β-Amyloid Peptide Discordant Segment, 2016, PLOS ONE, 11, e0154327.

 

  • Chi-Jen Lo, Chih-Ching Wang, Hsien-bin Huang, Chi-Fon Chang, Ming-Shi Shiao, Yi-Cheng Chen* and Ta-Hsien Lin* Arctic mutation accelerates Aβ aggregation in SDS through reducing the helical propensity of residues 15-25, 2015, Amyloid, 22, 8-18.

 

  • Yu-Jun Hu, Deli Irene, Chi-Jen Lo, Yong-Liang Cai, T.-C. Tzen, Ta-Hsien Lin and Chia-Lin Chyan*, Resonance assignments and secondary structure of a phytocystatin from Sesamum indicum, 2015, Biomol. NMR Assign., 9, 309-311.

 

  • Chi-Jen Lo, Chia-Lin Chyan, Yi-Chen Chen, Chi-Fon Chang, Hsien-bin Huang* and Ta-Hsien Lin*, Resonance assignments and secondary structure of apolipoprotein E C-terminal domain in DHPC micelles, 2015, Biomol. NMR Assign., 9, 187-190.

 

  • Chih-Kai Chang, Wei-An Chen, Chao-Yu Sie, Shen-Chieh Lin, Lilian Tsai-Wei Lin, Ta-Hsien Lin, Cheng-Che Hsu*, Steven S.-S. Wang* Investigating the effects of plasma pretreatment on the formation of ordered aggregates of lysozyme, 2015, Colloids and Surfaces B: Biointerfaces, 126, 154–161.

 

  • Deli Irene, Fu-Hsing Sung, Jian-Wen Huang, Ta-Hsien Lin, Yi-chen Chen and Chia-Lin Chyan* Resonance assignments and secondary structure of calmodulin in complex with its target sequence in rat olfactory cyclic nucleotide-gated ion channel, 2014, Biomol. NMR Assign., 8, 97-102.

 

  • Shu-Hsiang Huang, Shyue-Chu Ke, Ta-Hsien Lin, Hsin-Bin Huang, Yi-Cheng Chen* Effect of C-Terminal Residues of Aβ on Copper Binding Affinity, Structural Conversion and Aggregation, 2014, PLOS ONE, 9, e90385.

 

  • Yu-Shan Lin, Hsien-Lu Huang, Weiting Liu, Ta-Hsien Lin*, and Hsien-bin Huang* Identification of the high molecular weight isoform of phostensin, 2014, Int. J. Mol. Sci., 15, 1068-1079.

 

  • Chen-Yuan Kao, Jun-Kun Lai, Ta-Hsien Lin, Yu-Jiun Lin, Jeng-Shiung Jan∗, Steven S.-S. Wang∗ Examining the inhibitory actions of copolypeptides against amyloidfibrillogenesis of bovine insulin, 2013, Biochemical Engineering Journal, 78, 181-188.

 

  • Yi-Ru Chen, Hsien-bin Huang, Chi-Jen Lo, Chih-Ching Wang, Li-Kang Ho, Hsin-Tzu Liu, Ming-Shi Shiao, Ta-Hsien Lin*, Yi-Cheng Chen* Effect of Alanine Replacement of L17 and F19 on the Aggregation and Neurotoxicity of Arctic-Type Aβ40, 2013, PLOS ONE, 8, e61847.

 

  • Deli Irene, Jian-Wen Huang, Tse-Yu Chung, Feng-Yin Li, Jason T.-C. Tzen, Ta-Hsien Lin and Chia-Lin Chyan* Binding orientation and specificity of calmodulin to rat olfactory cyclic nucleotide-gated ion channel,2013, J. Biomol. Struct. Dyn., 34, 414-425.

 

  • Tzu-Fan Wang, Ning-Sheng Lai, Kuang-Yung Huang, Hsien-Lu Huang, Ming-Chi Lu, Yu-Shan Lin, Chun-Yu Chen, Su-Qin Liu, Ta-Hsien Lin* and Hsien-Bin Huang* Identification and Characterization of the Actin-Binding Motif of Phostensin, 2012, Int. J. Mol. Sci., 13, 15967-15982.

 

  • Chih-Ching Wang, Hsien-bin Huang, Huey-Jen Tsay, Ming-Shi Shiao, Wen-Jin Winston Wu, Yi-Chen Chen* and Ta-Hsien Lin* Characterization of Aβ aggregation mechanism probing by Congo red, 2012, J. Biomol. Struct. Dyn., 30, 160-169.

 

 

瀏覽數  
將此文章推薦給親友
請輸入此驗證碼
Voice Play
更換驗證碼