蔡英傑 Ying-Chieh Tsai | 個人簡歷 |  | 職稱: 教授 學歷: PhD in Agriculture, Tokyo University 辦公室: 傳醫乙棟 五樓 R512 室電話: 886-2-28267125Email:
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個人網頁: | | 研究領域--生物膜,乳酸菌,及本草精油之基礎及產業應用研究 | | Scientific aromatherapy and functional studies of essential oils from Chinese herbs | | Structural and functional studies of industrial enzymes (expandase, aminoacylase, saccharide oxidase) | | Inhibitors of sialyltransferase and fucosyltransferase and their anti-cancer, anti-infection activities | | Plant-derived lactic acid bacteria | | Wound healing mechanism of sulbogin and other Chinese herbs | | 研究著作(2003-2008) | Wei, C.L., Yan,g Y.B., Wang, W.C., Liu, W.C., Hsu, J.S., and Tsai, Y.C.* (2003) Engineering Streptomyces clavuligerus deacetoxycephalosporin C synthase for optimal ring expansion activity toward penicillin G. Appl. Environ. Microbiol. 69:2306-2312. Liaw, S.H, Chen, S.J, Ko, T.P, Hsu, C.S, Chen, C.J, Wang, A.H, and Tsai, Y.C.* (2003) Crystal structure of D-aminoacylase from Alcaligenes faecalis DA1. A novel subset of amidohydrolases and insights into the enzyme mechanism. J. Biol. Chem. 278:4957-62. Mai, L.M., Lin, C.Y., Chen, C.Y., and Tsai, Y.C.* (2003) Synergistic effect of bismuth subgallate and borneol, the major components of Sulbogin, on the healing of skin wound. Biomaterials. 24:3005-3012. Mei, H.C., Li, Y.F., Hsu, C.C., Tsai, Y.C.*, and Takagi, H.* (2003) Conversion of the cleavage specificity of subtilisin YaB on oxidized insulin chains to an elastase-like specificity by replacement of Gly124 with Ala. Biosci. Biotechnol. Biochem. 67:1601-1604. Shaw, C.Y., Chen, C.H., Hsu, C.C., Chen, C.C., and Tsai, Y.C.* (2003) Antioxidant properties of scopoletin isolated from Sinomonium acutum. Phytoth. Res. 17:823-825. Wang, P.H.*, Lee, W.L., Lee, Y.R., Juang,C.M., Chen, Y.J., Chao, H.T., Tsai, Y.C. and Yuan, C.C. (2003) Enhanced expression of a-sialyltransferase ST6Gal I in cervical squamous cell carcinoma. Gynecol. Oncol. 89:395-401. Lin, C.Y. , Shen, Y.H. , Wu, S.H. , Lin, C.H. , Hwang, S.M. and Tsai, Y.C.* (2004) Effect of bismuth subgallate on nitric oxide and prostaglandin E2 production by macrophages. Biochem. Biophys. Res. Commun. 315: 830-835. Lai, W.L., Chou, L.Y., Ting, C.Y., Kirby, R., Tsai, Y.C., Wang, A.H.J., and Liaw, S.H.* (2004) The functional role of the binuclear metal center in D-aminoacylase one-metal activation and second-metal attenuation. J. Biol. Chem. 279:13962-7. Huang, H.Y., Chang, C.K., Tso, T.K., Huang, J.J., Chang, W.W., and Tsai, Y.C.* (2004) Antioxidant activities of various fruits and vegetable produced in Taiwan.Inter. J. Food Sci. Nutr. 55:423-429. Hsu, J.S., Yang, Y.B., Deng, C.H., Wei, C.L., Liaw, S.H., and Tsai, Y.C.* (2004) Family shuffling of expandase genes to enhance substrate specificity for penicillin G. Appl. Environ. Microbiol. 70: 6257-6263. Lin, Y.H., Li, Y.F., Huang, M.C. and Tsai, Y.C.*(2004) Intracellular expression of Vitreoscilla haemoglobin in Aspergillus terreus to alleviate the effect of a short break in aeration during culture. Biotechnol. Lett. 26: 1067-1072. Huang, H.Y, Huang, J.J, Tso, T.K, Tsai, Y.C, Chang, C.K. (2004) Antioxidant and angiotension-converting enzyme inhibition capacities of various parts of Benincasa hispida (wax gourd). Nahrung. 48:230-3. Hsu, C.C., Lin, T.W., Chang, W.W., Lo, W.H., Wang, P.H., and Tsai, Y.C.* (2005) Soyasaponin I modified invasive behavior of cancer by changing cell surface sialic acids. Gynecol. Oncol. 96:415-422. Lin, T.W. ,Chang, W.W., Chen, C.C. and Tsai, Y.C.* (2005) Stachybotrydial, a potent inhibitor of fucosyltransferase and sialyltransferase. Biochem. Biophys. Res. Commun. 331:953-7 Huang C. H., Lai W. L., Lee, M. H., Chen C. J., Tsai, Y. C.* and Liaw, S. H.* (2005) Crystal structure of Acremonium strictum glucooligosaccharide oxidase. A novel flavinylation of 6-S-cysteinyl, 8a-N1-histidyl FAD. J. Biol. Chem. 280:38831-38838. Wei, C.L., Yang, Y.B., Deng, C.H., Liu, W.C., Hsu, J.S., Lin, Y.C., Liaw, S.H., and Tsai, Y.C.* (2005) Directed evolution of Streptomyces clavuligerus Deacetoxy-cephalosporin C synthase for enhancement of Penicillin G expansion. Appl. Environ. Microbiol. 71:8873-8880 Lee, M.H., Lai, W.L., Lin, S.F., Hsu, C.S., Liaw, S.H. and Tsai, Y.C.* (2005) Structural characterization of glucooligosaccharide oxidase from Acremonium strictum. Appl. Environ. Microbiol. 71:8881-8887. Chao, S.H., Cheng, T.H., Shaw, C.Y., Lee, M.H., Hsu, Y.H., and Tsai, Y.C.* (2006) Characterization of a novel PepF-like oligopeptidase that is secreted from Bacillus amyloliquefaciens 23-7A. Appl. Environ. Microbiol. 72:968-971. Chang, W.W., Yu, C.Y., Lin, T.W., Wang P.H., Tsai, Y.C.* (2006) Soyasaponin I decreases the expression of a2,3-linked sialic acid on the cell surface and suppresses the metastatic potential of B16F10 melanoma cells. Biochem. Biophys. Res. Commun. 341: 614-619 Lee, M.H., Lai, W.L., Lin, S.F., Liu, Y., Hsu, Y.H. and Tsai, Y.C.* (2006) Purification and characterization of a novel cellooligosaccharide oxidase from rice pathogen Sarocladium oryzae. Enzyme Microbiol. Tech. 39:85-91. Hsu, H.C., Yang, W.C., Tsai W.J., Chen, C.C., Huang, H.Y., and Tsai, Y.C.* (2006) a-Bulnesene, a novel PAF receptor antagonist isolated from Pogostemon cablin. Biochem. Biophys. Res. Commun. 345:1033-38. Tsai, Y.C.,* and Hsu, H.C., Yang, W.C., Tsai, W.J., Chen, C.C., Watanabe, T. (2007) a-Bulnesene, a PAF inhibitor isolated from the essential oil of Pogostemon cablin. Fitoterapia 78:7-11. Wang, P. H., * Lee, W. L., Yang, Y. H., Chen, Y. J., Tsai, Y. C. and Yuan, C. C. (2007) Alpha 2,6-sialyltransferase I expression in the placenta of patients with preeclampsia. J. Chin. Med. Assoc. 70:152-8. Chao, S. H., Tomii, Y., Watanabe, H., and Tsai, Y. C. * (2008) Diversity of lactic acid bacteria in fermented brines used to make stinky tofu. Int. J. Food Microbiol. 123:134-141.
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